I ended up with thrush as a side effect of another drug. Since my doctor was on leave and I could not get Diflucan prescribed, I bought Miconazole cream. As suggested, I used the suppository a few hours before bed time and applied the cream liberally. It helped clear me up and within 3-5 days, all symptoms of my infection were gone. I have never had any side effects with this drug apart from the one time during pregnancy. But for that instance, I would rather blame my impatience than blame the drug. I have always found that a warm bath helps with the itching and makes the cream more effective. But at that point my pregnancy hormones were all over the place and I was feeling so crazy that I could not even think of waiting for a bath. That made a whole lot of difference in the treatment.