I have had moderate level facial acne since my teenage years, which means I have basically been battling this thing for about a decade now. Having tried many remedies, I finally decided to take my chances with Isotrex gel a few months ago. I was prescribed to start with an initial dose of 20mg with an increment of 10mg per month after that. I have had varied side effects, but none of them have been drastic. But what is interesting is that my side effects have changed every month with the change in the dosage.For the 1st month, I had experienced over all dryness in my body and especially very dry lips, and a mild body ache. I also saw some new pimples popping up.By the next month when the dosage increased; my side effects from the previous month were gone. Instead; I had to deal with split ends in my hair, eyes becoming sensitive to sunlight, and an extreme aversion towards all oily food. I have just started my 3rd month a few days back and so am waiting to see if these side effects stick or they change again. Also, I have started taking a multivitamin and drink up to a gallon of water daily. My observation is that it is helping to counter the side effects but whether it is effective or not, only time will tell.